ChloroquineV1, Main, Exploration, bibRecord, 000C77

Molecular surveillance of Plasmodium falciparum resistance to artemisinin-based combination therapies in the Democratic Republic of Congo

Identifieur interne : 000C77 ( Main/Exploration ); précédent : 000C76; suivant : 000C78

Molecular surveillance of Plasmodium falciparum resistance to artemisinin-based combination therapies in the Democratic Republic of Congo

Auteurs : Dieudonneé Makaba Mvumbi [République démocratique du Congo] ; Thierry Lengu Bobanga [République démocratique du Congo] ; Jean-Marie Ntumba Kayembe [République du Congo] ; Georges Lelo Mvumbi [République démocratique du Congo] ; Hippolyte Nani-Tuma Situakibanza [République démocratique du Congo] ; F. Benoit-Vical [France] ; Pierrette Melin [Belgique] ; P. De Mol [Belgique] ; Marie-Pierre Hayette [Belgique]

Source :

PLoS ONE [ 1932-6203 ] ; 2017.

RBID : Hal:hal-01947825

Abstract

Malaria is a major public health problem in the Democratic Republic of Congo. Despite progress achieved over the past decade in the fight against malaria, further efforts have to be done such as in the surveillance and the containment of Plasmodium falciparum resistant strains. We investigated resistance to artemisinin-based combination therapies currently in use in Democratic Republic of Congo by surveying molecular polymorphisms in three genes: pfcrt, pfmdr1 and pfk13 to explore possible emergence of amodiaquine, lumefantrine or artemisinin resistance in Democratic Republic of Congo. This study essentially revealed that resistance to chloroquine is still decreasing while polymorphism related to amodiaquine resistance seems to be not present in Democratic Republic of Congo, that three samples, located in the east of the country, harbor Pfmdr1 amplification and that none of the mutations found in South-East Asia correlated with artemisinine resistance have been found in Democratic Republic of Congo. But new mutations have been identified, especially the M476K, occurred in the same position that the M476I previously identified in the F32-ART strain, strongly resistant to artemisinine. Antimalarial first-line treatments currently in use in Democratic Republic of Congo are not associated with emergence of molecular markers of resistance.

Url:

https://hal.archives-ouvertes.fr/hal-01947825

DOI: 10.1371/journal.pone.0179142

Affiliations:

Belgique, France, République du Congo, République démocratique du Congo

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Le document en format XML

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<author><name sortKey="Situakibanza, Hippolyte Nani Tuma" sort="Situakibanza, Hippolyte Nani Tuma" uniqKey="Situakibanza H" first="Hippolyte Nani-Tuma" last="Situakibanza">Hippolyte Nani-Tuma Situakibanza</name>
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          <desc>            <address>              <addrLine> University of Kinshasa, Kinshasa</addrLine>
              <country key="CD"></country>
            </address>
            <ref type="url">https://facmed-unikin.net/departement-de-medecine-tropicale-maladies-infectieuses-et-parasitaires/</ref>
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            <ref type="url">http://www.unikin.cd/</ref>
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<country>République démocratique du Congo</country>
</affiliation>
</author>
<author><name sortKey="Benoit Vical, F" sort="Benoit Vical, F" uniqKey="Benoit Vical F" first="F." last="Benoit-Vical">F. Benoit-Vical</name>
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          <idno type="RNSR">197417418A</idno>
          <orgName>Laboratoire de chimie de coordination</orgName>
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          <date type="start">1974-01-01</date>
          <desc>            <address>              <addrLine>205 Route de Narbonne 31077 TOULOUSE CEDEX 4</addrLine>
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          <orgName>Institut National Polytechnique (Toulouse)</orgName>
          <orgName type="acronym">Toulouse INP</orgName>
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<tutelle active="#struct-443875" type="indirect"><org type="regroupinstitution" xml:id="struct-443875" status="VALID">          <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName>
          <desc>            <address>              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"></country>
            </address>
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          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <desc>            <address>              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
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          <orgName>Institut de Chimie de Toulouse</orgName>
          <orgName type="acronym">ICT-FR 2599</orgName>
          <desc>            <address>              <addrLine>118 Route de Narbonne 31062 Toulouse cédex 9</addrLine>
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<country>France</country>
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</author>
<author><name sortKey="Melin, Pierrette" sort="Melin, Pierrette" uniqKey="Melin P" first="Pierrette" last="Melin">Pierrette Melin</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-548773" status="VALID">          <orgName>Département de microbiologie clinique, Centre Hospitalier Universitaire de Liège</orgName>
          <orgName type="acronym">CHU Liège</orgName>
          <desc>            <address>              <addrLine>Domaine Universitaire du Sart TilmanBâtiment B 35B-4000 Liège</addrLine>
              <country key="BE"></country>
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            <ref type="url">https://www.chu.ulg.ac.be/jcms/c_11494/fr/microbiologie-clinique</ref>
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          <desc>            <address>              <country key="BE"></country>
            </address>
          </desc>
        </org>
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</hal:affiliation>
<country>Belgique</country>
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</author>
<author><name sortKey="De Mol, P" sort="De Mol, P" uniqKey="De Mol P" first="P." last="De Mol">P. De Mol</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-548773" status="VALID">          <orgName>Département de microbiologie clinique, Centre Hospitalier Universitaire de Liège</orgName>
          <orgName type="acronym">CHU Liège</orgName>
          <desc>            <address>              <addrLine>Domaine Universitaire du Sart TilmanBâtiment B 35B-4000 Liège</addrLine>
              <country key="BE"></country>
            </address>
            <ref type="url">https://www.chu.ulg.ac.be/jcms/c_11494/fr/microbiologie-clinique</ref>
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          <orgName type="acronym">CHU-Liège</orgName>
          <desc>            <address>              <country key="BE"></country>
            </address>
          </desc>
        </org>
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</hal:affiliation>
<country>Belgique</country>
</affiliation>
</author>
<author><name sortKey="Hayette, Marie Pierre" sort="Hayette, Marie Pierre" uniqKey="Hayette M" first="Marie-Pierre" last="Hayette">Marie-Pierre Hayette</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-548773" status="VALID">          <orgName>Département de microbiologie clinique, Centre Hospitalier Universitaire de Liège</orgName>
          <orgName type="acronym">CHU Liège</orgName>
          <desc>            <address>              <addrLine>Domaine Universitaire du Sart TilmanBâtiment B 35B-4000 Liège</addrLine>
              <country key="BE"></country>
            </address>
            <ref type="url">https://www.chu.ulg.ac.be/jcms/c_11494/fr/microbiologie-clinique</ref>
          </desc>
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          <orgName type="acronym">CHU-Liège</orgName>
          <desc>            <address>              <country key="BE"></country>
            </address>
          </desc>
        </org>
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</hal:affiliation>
<country>Belgique</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1371/journal.pone.0179142</idno>
<series><title level="j">PLoS ONE</title>
<idno type="ISSN">1932-6203</idno>
<imprint><date type="datePub">2017</date>
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<front><div type="abstract" xml:lang="en">              <p>Malaria is a major public health problem in the Democratic Republic of Congo. Despite progress achieved over the past decade in the fight against malaria, further efforts have to be done such as in the surveillance and the containment of Plasmodium falciparum resistant strains. We investigated resistance to artemisinin-based combination therapies currently in use in Democratic Republic of Congo by surveying molecular polymorphisms in three genes: pfcrt, pfmdr1 and pfk13 to explore possible emergence of amodiaquine, lumefantrine or artemisinin resistance in Democratic Republic of Congo. This study essentially revealed that resistance to chloroquine is still decreasing while polymorphism related to amodiaquine resistance seems to be not present in Democratic Republic of Congo, that three samples, located in the east of the country, harbor Pfmdr1 amplification and that none of the mutations found in South-East Asia correlated with artemisinine resistance have been found in Democratic Republic of Congo. But new mutations have been identified, especially the M476K, occurred in the same position that the M476I previously identified in the F32-ART strain, strongly resistant to artemisinine. Antimalarial first-line treatments currently in use in Democratic Republic of Congo are not associated with emergence of molecular markers of resistance.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>Belgique</li>
<li>France</li>
<li>République du Congo</li>
<li>République démocratique du Congo</li>
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</list>
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<name sortKey="Bobanga, Thierry Lengu" sort="Bobanga, Thierry Lengu" uniqKey="Bobanga T" first="Thierry Lengu" last="Bobanga">Thierry Lengu Bobanga</name>
<name sortKey="Mvumbi, Georges Lelo" sort="Mvumbi, Georges Lelo" uniqKey="Mvumbi G" first="Georges Lelo" last="Mvumbi">Georges Lelo Mvumbi</name>
<name sortKey="Situakibanza, Hippolyte Nani Tuma" sort="Situakibanza, Hippolyte Nani Tuma" uniqKey="Situakibanza H" first="Hippolyte Nani-Tuma" last="Situakibanza">Hippolyte Nani-Tuma Situakibanza</name>
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<country name="République du Congo"><noRegion><name sortKey="Kayembe, Jean Marie Ntumba" sort="Kayembe, Jean Marie Ntumba" uniqKey="Kayembe J" first="Jean-Marie Ntumba" last="Kayembe">Jean-Marie Ntumba Kayembe</name>
</noRegion>
</country>
<country name="France"><noRegion><name sortKey="Benoit Vical, F" sort="Benoit Vical, F" uniqKey="Benoit Vical F" first="F." last="Benoit-Vical">F. Benoit-Vical</name>
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</country>
<country name="Belgique"><noRegion><name sortKey="Melin, Pierrette" sort="Melin, Pierrette" uniqKey="Melin P" first="Pierrette" last="Melin">Pierrette Melin</name>
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<name sortKey="De Mol, P" sort="De Mol, P" uniqKey="De Mol P" first="P." last="De Mol">P. De Mol</name>
<name sortKey="Hayette, Marie Pierre" sort="Hayette, Marie Pierre" uniqKey="Hayette M" first="Marie-Pierre" last="Hayette">Marie-Pierre Hayette</name>
</country>
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</record>

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Molecular surveillance of Plasmodium falciparum resistance to artemisinin-based combination therapies in the Democratic Republic of Congo

Molecular surveillance of Plasmodium falciparum resistance to artemisinin-based combination therapies in the Democratic Republic of Congo

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